...and you're gonna let as many roar as you need to cause maximum damage to the non-fundamentalist Islamic world as possible, without mercy. Nowhere is safe. You're doing it for the Faith as a whole and for the long term so symbolic hits would be a waste.
The attack would be followed up by coordinated personnel movements to take over societies throwing much of the planet into a Sharia dark age. You'd need to demolish military resistance by at least 75%.
The nukes aren't missile-borne. They were shipped, or driven, or flown, or planted.